(CNN) -- An unmanned NASA-contracted rocket exploded early Tuesday evening along the eastern Virginia coast, causing a huge fireball but no apparent deaths.
According to NASA, the Orbital Sciences Corp.'s Antares rocket and Cygnus cargo spacecraft were set to launch at 6:22 p.m. ET from the Wallops Flight Facility along the Atlantic Ocean. It was set to carry some 5,000 pounds of supplies and experiments to the International Space Station.
"There was failure on launch," NASA spokesman Jay Bolden said. "There was no indicated loss of life."
Bolden added, "There was significant property and vehicle damage. Mission control is trying to assess what went wrong."
Video shows the rocket rising into the air for a few seconds before an explosion. It then plummets back to Earth, causing more flames as it hits the ground. NASA tweeted that the failure occurred six seconds after launch.
Afterward, the launch director said on NASA's feed that all personnel were accounted for and that no injuries were reported.
He added that the spacecraft contained "classified ... equipment," and that there was a need to maintain the area around the debris field for investigative and potential security reasons given what was on board.
The launch had been scheduled for Monday, but that was scrubbed "because of a boat down range in the trajectory Antares would have flown had it lifted off," according to NASA.
Just before Tuesday's liftoff, the space agency reported "100% favorable" weather and "no technical concerns with the rocket or spacecraft being worked."
About one-third of the spacecraft's cargo consisted of material for scientific investigations, including a Houston school's experiment on pea growth and a study on blood flow in space.
There was about the same amount of cargo for supplies for the space station's crew, including more than 1,300 pounds of food.
CNN's Chandler Friedman contributed to this report.