He`s been on the run for six months after escaping prison through an elaborate underground tunnel, and though police scour the world - even offer a $5M reward - no one can find him.
Except Hollywood actor Sean Penn.
Before Mexican authorities put the cuffs on Shorty again last week, Penn had a full-on, sit-down interview.
In Rolling Stone Magazine, Penn describes the difficulty getting to El Chapo: "Tracphones (burners), one per contact, one per day, destroy, burn, buy..."
It seems Penn and Shorty`s secret meeting went down because of Shorty`s ego. He badly wanted a biopic made of his life, so who else do you call besides a big movie star with a bad boy reputation?
Penn, along with Mexican actress Kate Del Castillo (reportedly a friend of Guzman`s) hung out with him at his mountain hideout.
In an online video, filmed after Penn sent follow up questions, you can even hear the squawking chickens in the background as El Chapo talks about the dangers of drugs.
"Well it`s a reality that drugs destroy unfortunately as I said where I grew up there's no other way, there still isn`t a way to survive," said Guzman on camera in Spanish with an English interpreter's voice on the video. El Chapo said when he`s gone there will be no reduction in drugs or addictions.
The interview reportedly took place three months after his escape from a maximum security prison in Mexico.
El Chapo is set to be extradited to the U.S. this summer, if he doesn`t escape for a third time .