KABUL , Afghanistan-- An attacker driving an ambulance packed with explosives detonated them Saturday in the Afghan capital of Kabul, leaving 95 people dead and 158 others injured, Afghan officials said.
Taliban spokesman Zabiullah Mojahid claimed responsibility for the attack, which comes a week after militants stormed a Kabul hotel.
The blast occurred around 12:45 p.m. local time after the vehicle passed through a security checkpoint, Interior Ministry spokesman Nasrat Rahimi told CNN.
Police identified the attacker at a second checkpoint, Rahimi said, but couldn't stop him before he detonated the explosives in a central area near the old Interior Ministry building, a hospital and diplomatic buildings.
The injured have been taken to hospitals across the Afghan capital, said spokesman Wahid Majrooh of the Ministry of Public Health, who confirmed the casualties. He said the toll was likely to rise.
The attack, in the heart of what's meant to be the securest part of the city, is likely to fuel doubts over the Afghan authorities' ability to keep people safe.
It comes a week after gunmen attacked the Intercontinental Hotel in Kabul, killing at least 22 people during a 12-hour standoff with Afghan security forces. Six gunmen were killed. The Taliban also claimed responsibility for that assault.
ISIS militants on Wednesday attacked the offices of British aid agency Save the Children in the eastern Afghan city of Jalalabad, killing at least four people and injuring dozens.
US general was in Kabul
The head of US Central Command, Gen. Joseph Votel, was in Kabul at the time of Saturday's explosion, US military officials said. He was in meetings with Afghan officials less than two miles away.
"It was a large explosion that did not escape the attention of any of our people in Kabul," a statement from Central Command said.
"The general was never threatened and was not adversely affected by the explosion. We do express our condolences to those who were directly affected," the statement said.
The officials said Votel maintained his schedule and did not leave any meetings early.
US Secretary of State Rex Tillerson condemned the "horrific" attack.
"Our thoughts are with the families of the victims who were injured and killed, and we mourn all of those who lost their lives in this senseless attack," Tillerson said in a statement. "The Taliban's use of an ambulance as a weapon to target civilians represents inhumane disregard for the people of Afghanistan and all those working to bring peace to the country, and is a violation of the most basic international norms."
'Insane, inhuman, heinous'
Afghanistan's chief executive, Abdullah Abdullah, described the attack as "insane, inhuman, heinous and a warcrime" via his official Twitter account.
He also called on the international community to "take further action" against "state-sponsored terrorism."
"Our priority and focus right now is to help those in need and provide the best treatment for those wounded," he wrote. "This is the moment when we all need to stand together and punch our enemy hard. This is enough!"
The head of the UN mission in Afghanistan said the attack was "nothing short of an atrocity" that targeted a civilian area.
"While the Taliban claim suggested the purpose of the attack was to target police, a massive vehicle bomb in a densely populated area could not reasonably be expected to leave civilians unharmed," Tadamichi Yamamoto said in a statement.
"I am particularly disturbed by credible reports that the attackers used a vehicle painted to look like an ambulance, including bearing the distinctive medical emblem, in clear violation of international humanitarian law."
John Bass, US ambassador to Afghanistan, called it a "senseless and cowardly bombing."
"My government and I stand with the brave people of Afghanistan. Their work to create a peaceful, prosperous future for all the citizens of this country is the best response to terrorists and others who know only violence," Bass said in a statement.
Analysis: Attack shows strongholds are vulnerable
Saturday's bombing was not just another attack in the Afghan capital, CNN senior international correspondent Nick Paton Walsh said.
Every time the so-called ring of steel in the city is penetrated, especially to such devastating effect, it undermines the government's ability to appear in control of even its most important sanctuaries, he said.
At a time when President Ashraf Ghani faces internal enemies and is far from secure, the perception that even his inner enclaves are vulnerable is damaging.
Secondly, the Taliban's swift claim of responsibility was in marked contrast to a March attack on a key military hospital in Kabul that killed at least 30 people, many of them doctors and injured soldiers, Paton Walsh said.
The Taliban denied it was behind the hospital attack, suggesting such targets were beyond the pale. ISIS eventually made a reasonably credible claim to that attack.
This time, the Taliban had no such qualms, Paton Walsh said. It's possibly a sign the Taliban doesn't want to lose out to its younger, nastier competitor insurgency in the extremism stakes. A year ago, medical facilities were off-limits; now, an ambulance can be used as a bomb.
Thirdly, this is a seminal moment in the 16-year Afghanistan War. Last year, US and Afghan officials accepted that things had not gone well -- that territory was lost -- but noted the Taliban had lost people, too. This year, they insist, is the year the Taliban will begin to lose territory again. Attacks such as this not only diminish morale but show strongholds as vulnerable, Paton Walsh said.
This year, too, hundreds more US troops are en route to the country to begin a much riskier mission: training Afghan troops outside the wire. There will be Americans on the front line who know that combat may be part of their mission and who may die in that effort, Paton Walsh said.
This is the one key foreign policy issue upon which US President Donald Trump has made a specific policy pledge: to win.
At the same time, key indicators about how well the US and Afghan forces are doing -- such as how many Afghan soldiers or police are killed or injured -- are being classified, depriving the American public of simple ways of assessing their President's success, Paton Walsh said, noting that neither the Pentagon or this White House typically hide it when they are winning.