The crash happened at the intersection of Pinemont Drive and Ella Boulevard.
Houston police said the 29-year-old motorcyclist, riding a green Kawasaki Ninja ZX motorcycle and traveling eastbound on Pinemont, ran a red light and crashed into a white Dodge Ram pickup truck going northbound on Ella. The motorcyclist was declared dead at the scene by paramedics.
The 37-year-old driver of the pickup truck remained at the scene and cooperated with police. No charges were filed against the driver as of Friday morning, police said.
The investigation is continuing, police said.
The intersection remained closed for another hour and a half before reopening.