It happened shortly after 2:10 a.m. at 3299 Reed Road, near Rosehaven Drive.
Police said a driver of a black Buick Lacrosse was eastbound on Reed Road when a nude man stepped out onto the roadway. He was not in a crosswalk, police said.
The driver was unable to stop in time and struck him. The driver stayed at the scene and called police.
The victim, who is yet to be identified, was pronounced dead at the scene.
The driver cooperated with officers while an investigation is underway. Officers said the driver showed signs of intoxication and was subsequently arrested.
The driver is facing charges for driving while intoxicated.